A Production Deficiency Is Best Described as

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FGF23 a newly described phosphaturic hormone inhibits renal production of 125OH 2 D by inhibiting 1-α-hydroxylase in the renal proximal tubule and by simultaneously increasing the expression of 24-α-hydroxylase and production of 2425OH 2 D an inactive metabolite. The endogenous production was 20 lower in non-white skin phototype patients and was decreased by 16 during autumn winter.


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125OH 2 D stimulates FGF23 creating a feedback loop.

. The effects of season and skin phototype were significant on production rate. Among 422 HIV-infected patients 25OHD pharmacokinetics were best described by a one compartment model with an additional endogenous production.


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